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Background of technology development

Proteins play a crucial role in biological processes, making them key elements in understanding these phenomena. The emergence of new technologies, such as predictive AI systems, has sparked interest in advancing protein research.
The "mass spectrometer" has evolved over time to detect proteins, but its pre-treatment requirements and reliance on large equipment present challenges. Further technological advancements are expected to make protein detection more widespread.

(improved enzyme cycling method)

1. Ultrasensitive protein detection (LOD is under 1 pg/mL)
2. Simple and no dedicated equipment required
3. Applicable to a wide variety of biomarkers

Therefore, BioPhenoMA was established with the goal of creating an innovative platform that makes it easy for anyone to detect ultra-trace proteins anywhere.
Our core technology, developed by Professor Etsuro Ito and his team, combines the conventional sandwich ELISA method and the enzyme cycling method. This cutting-edge technology allows for the detection of minute amounts of proteins without the need for extensive equipment or time-consuming pre-treatment. It reached a zeptomole detection limit (10-21mol/assay), making it a champion data for protein detection.

By providing this innovative technology to the market, BioPhenoMA aims to promote the discovery of new drugs and therapeutic targets, elucidate drug action mechanisms, streamline drug development, and realize personalized medicine. We are dedicated to advancing the biomedical field through our contributions.

​Conventional method


TN-cyclon™(improved enzyme cycling method)

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